{"schema_version":"secwatch.filing_event.v1","accession":"0001125345-24-000151","form_type":"8-K","ticker":"MGNX","cik":"0001125345","company_name":"MACROGENICS INC","filed_at":"2024-09-16T23:59:59+00:00","discovered_at":"2026-05-14T18:03:12.234261+00:00","generated_at":"2026-05-31T04:29:08.745693+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"neutral","materiality_score":0.7,"calibrated_materiality_score":0.7,"confidence":"high","headline":"MacroGenics TAMARACK Phase 2 data: 6-month rPFS 69-70%, ORR up to 40.6%, but 8 treatment-related deaths","bullets":["6-month radiographic PFS rate 69% (2.0 mg/kg) and 70% (2.7 mg/kg); median rPFS ~8.5 and 7.5 months (immature).","Confirmed ORR 20.0% (2.0 mg/kg) and 40.6% (2.7 mg/kg) among RECIST-evaluable patients.","Median 6 doses received (range 1-12); 25.6% (2.0 mg/kg) and 18.6% (2.7 mg/kg) remained on drug at data cutoff.","Grade ≥3 TEAEs: 65.6% (2.0 mg/kg) and 62.8% (2.7 mg/kg); discontinuation rates 25.6% and 38.4%.","8 fatal treatment-related AEs (5 in 2.0 mg/kg, 3 in 2.7 mg/kg) including pneumonitis and cardiac events."],"urls":{"canonical":"https://secwatch.observer/filing/0001125345-24-000151","json":"https://secwatch.observer/filing/0001125345-24-000151.json","markdown":"https://secwatch.observer/filing/0001125345-24-000151.md","text":"https://secwatch.observer/filing/0001125345-24-000151.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1125345/000112534524000151/0001125345-24-000151-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1125345/000112534524000151/mgnx-20240916.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-31T04:29:08.745693+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}