{"schema_version":"secwatch.filing_event.v1","accession":"0001125345-26-000050","form_type":"8-K","ticker":"MGNX","cik":"0001125345","company_name":"MACROGENICS INC","filed_at":"2026-07-23T20:07:30+00:00","discovered_at":"2026-07-23T20:08:00.230888+00:00","generated_at":"2026-07-23T20:08:08.525998+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"MacroGenics MGC026 Phase 1 meets SCCHN Stage 1 threshold; ESMO poster accepted","bullets":["MGC026, a B7-H3-directed ADC, achieved pre-specified Stage 1 response threshold in SCCHN cohort; Stage 2 enrollment underway.","Dose escalation completed; 7.5 mg/kg q3W selected for expansion in SCCHN, endometrial, melanoma, soft tissue sarcoma.","As of July 8, 2026, 74 patients enrolled; no interstitial lung disease or ocular toxicity reported.","Interim Phase 1 results accepted for poster at ESMO 2026 (Oct 23-27, Madrid); also lorigerlimab poster on gynecologic cancers.","CEO Eric Risser: 'look forward to sharing data at ESMO.'"],"urls":{"canonical":"https://secwatch.observer/filing/0001125345-26-000050","json":"https://secwatch.observer/filing/0001125345-26-000050.json","markdown":"https://secwatch.observer/filing/0001125345-26-000050.md","text":"https://secwatch.observer/filing/0001125345-26-000050.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1125345/000112534526000050/0001125345-26-000050-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1125345/000112534526000050/mgnx-20260723.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-07-23T20:08:08.525998+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}