secwatch.observer — SEC 8-K summary ====================================== Issuer: Cyclerion Therapeutics, Inc. (CYCN) CIK: 0001755237 Form: 8-K Filed at: 2021-09-30T23:59:59+00:00 Accession: 0001140361-21-033010 Event type: other_material Sentiment: neutral Materiality: 0.40 Item codes: 7.01, 9.01 LLM model: deepseek-v4-flash:cloud@v2 Cyclerion updates three CY6463 trials: CIAS Phase 1b enrolled, MELAS topline H1 2022, ADv screening -------------------------------------------------------------------------------- - First patients enrolled in Phase 1b study of CY6463 for cognitive impairment associated with schizophrenia (CIAS). - Phase 2a in MELAS remains enrolling; topline clinical results now expected in H1 2022. - Patient screening started in Phase 2a study of CY6463 for Alzheimer's disease with vascular pathology (ADv). Source: EDGAR index: https://www.sec.gov/Archives/edgar/data/1755237/000114036121033010/0001140361-21-033010-index.htm Primary doc: https://www.sec.gov/Archives/edgar/data/1755237/000114036121033010/brhc10029438_8k.htm HTML page: https://secwatch.observer/filing/0001140361-21-033010 License: Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer