{"schema_version":"secwatch.filing_event.v1","accession":"0001140361-24-032333","form_type":"8-K","ticker":"INSM","cik":"0001104506","company_name":"INSMED Inc","filed_at":"2024-07-03T23:59:59+00:00","discovered_at":"2026-05-14T18:03:12.185575+00:00","generated_at":"2026-05-31T23:26:43.165309+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"Insmed reports additional positive ASPEN data: brensocatib 25 mg slows lung function decline in bronchiectasis","bullets":["Brensocatib 25 mg showed significantly less FEV1 decline vs placebo (38 mL vs -62 mL; p=0.0054) at Week 52.","Brensocatib 25 mg also showed nominally significant FVC preservation (75 mL less decline; p<0.0001).","QOL-B Respiratory Symptom Score improved by 3.8 points with 25 mg dose vs placebo (p=0.0004).","Safety profile favorable; common TEAEs included COVID-19, nasopharyngitis, cough, headache.","Insmed plans to file NDA in Q4 2024; potential U.S. launch mid-2025, Europe/Japan H1 2026."],"urls":{"canonical":"https://secwatch.observer/filing/0001140361-24-032333","json":"https://secwatch.observer/filing/0001140361-24-032333.json","markdown":"https://secwatch.observer/filing/0001140361-24-032333.md","text":"https://secwatch.observer/filing/0001140361-24-032333.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1104506/000114036124032333/0001140361-24-032333-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1104506/000114036124032333/ef20031846_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-31T23:26:43.165309+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}