{"schema_version":"secwatch.filing_event.v1","accession":"0001140361-24-035233","form_type":"8-K","ticker":"IONS","cik":"0000874015","company_name":"IONIS PHARMACEUTICALS INC","filed_at":"2024-08-01T23:59:59+00:00","discovered_at":"2026-05-14T18:03:16.102699+00:00","generated_at":"2026-05-31T14:09:13.035315+00:00","sec_items":["2.02","9.01"],"event_type":"earnings","sentiment":"positive","materiality_score":0.7,"calibrated_materiality_score":0.7,"confidence":"high","headline":"Ionis Q2 revenue $225M (+20% YoY); operating loss narrows to $66M; key pipeline milestones","bullets":["Total revenue $225M (up 20% YoY); loss from operations $66M vs $91M loss in Q2 2023; non-GAAP loss from ops $35M.","WAINUA Q2 royalty revenue $4M; approved in Canada; U.S. launch progressing with AstraZeneca.","Olezarsen NDA for FCS accepted for Priority Review, PDUFA Dec 19, 2024; Phase 3 sHTG studies fully enrolled, data H2:2025.","Donidalorsen Phase 3 OASIS data published in NEJM; preparing U.S. NDA and EU MAA for HAE.","Cash and short-term investments $2.1B; reaffirmed 2024 guidance; projects year-end cash $1.7B."],"urls":{"canonical":"https://secwatch.observer/filing/0001140361-24-035233","json":"https://secwatch.observer/filing/0001140361-24-035233.json","markdown":"https://secwatch.observer/filing/0001140361-24-035233.md","text":"https://secwatch.observer/filing/0001140361-24-035233.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/874015/000114036124035233/0001140361-24-035233-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/874015/000114036124035233/ef20033414_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-31T14:09:13.035315+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}