{"schema_version":"secwatch.filing_event.v1","accession":"0001140361-24-041100","form_type":"8-K","ticker":"IMCR","cik":"0001671927","company_name":"Immunocore Holdings plc","filed_at":"2024-09-16T23:59:59+00:00","discovered_at":"2026-05-14T18:03:14.046992+00:00","generated_at":"2026-05-31T04:37:28.901723+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.7,"calibrated_materiality_score":0.7,"confidence":"high","headline":"Immunocore reports positive Phase 1 data for brenetafusp in ovarian cancer at ESMO 2024","bullets":["Phase 1 monotherapy: 58% disease control, 6.5% RECIST response rate, median PFS 3.3 months in heavily pre-treated platinum-resistant ovarian cancer.","Phase 1 combo with chemo: 23% RECIST response rate, 69% disease control, 82% ctDNA molecular response rate.","T cell fitness signature associated with OS (28 vs 11 months) and PFS (5 vs 2 months) for KIMMTRAK in uveal melanoma, across ImmTAC platform.","Brenetafusp well tolerated; no treatment-related discontinuations; cytokine release syndrome manageable (57% Grade 1)."],"urls":{"canonical":"https://secwatch.observer/filing/0001140361-24-041100","json":"https://secwatch.observer/filing/0001140361-24-041100.json","markdown":"https://secwatch.observer/filing/0001140361-24-041100.md","text":"https://secwatch.observer/filing/0001140361-24-041100.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1671927/000114036124041100/0001140361-24-041100-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1671927/000114036124041100/ef20035872_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-31T04:37:28.901723+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}