{"schema_version":"secwatch.filing_event.v1","accession":"0001140361-25-027949","form_type":"8-K","ticker":"IONS","cik":"0000874015","company_name":"IONIS PHARMACEUTICALS INC","filed_at":"2025-07-30T23:59:59+00:00","discovered_at":"2026-05-14T18:02:46.534099+00:00","generated_at":"2026-05-17T23:24:42.102241+00:00","sec_items":["2.02","9.01"],"event_type":"earnings","sentiment":"positive","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"Ionis Q2 revenue doubles to $452M; raises FY 2025 guidance, TRYNGOLZA sales $19M","bullets":["Q2 total revenue $452M (up from $225M); GAAP income from ops $140M vs loss $66M year ago.","TRYNGOLZA net product sales $19M in Q2, first half $26M; SPINRAZA royalties $54M, WAINUA royalties $10M.","FY 2025 guidance raised: total revenue $825-850M (from $725-750M); TRYNGOLZA sales guided at $75-80M.","Donidalorsen expected approval Aug 21, 2025; Phase 3 olezarsen sHTG data due September.","Received $280M upfront from sapablursen license; cash & investments $2.3B; CFO raised non-GAAP op loss guidance to $300-325M."],"urls":{"canonical":"https://secwatch.observer/filing/0001140361-25-027949","json":"https://secwatch.observer/filing/0001140361-25-027949.json","markdown":"https://secwatch.observer/filing/0001140361-25-027949.md","text":"https://secwatch.observer/filing/0001140361-25-027949.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/874015/000114036125027949/0001140361-25-027949-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/874015/000114036125027949/ef20052929_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-17T23:24:42.102241+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}