Ionis olezarsen OLE data: liver fat returns toward baseline after 24 months; 90%+ retention

IONIS PHARMACEUTICALS INC

Mean hepatic fat fraction (HFF) levels returned toward baseline after 24 months of olezarsen 80 mg in CORE-OLE study of severe hypertriglyceridemia.
Patients transitioning from 50 mg to 80 mg showed less pronounced HFF changes; safety profile remained favorable with longer treatment.
Over 90% of eligible patients from CORE/CORE2 studies enrolled and remained in the open-label extension.
Data presented at National Lipid Association Scientific Sessions in Chicago on June 12, 2026.

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