{"schema_version":"secwatch.filing_event.v1","accession":"0001140361-26-035802","form_type":"8-K","ticker":"IONS","cik":"0000874015","company_name":"IONIS PHARMACEUTICALS INC","filed_at":"2026-09-04T21:00:39+00:00","discovered_at":"2026-09-04T21:02:00.552358+00:00","generated_at":"2026-09-04T21:02:15.485953+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"negative","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Ionis partner Novartis: pelacarsen Phase 3 Lp(a)HORIZON misses primary CV endpoint","bullets":["Pelacarsen Phase 3 Lp(a)HORIZON did not meet primary endpoint of reducing CV events vs placebo (CV death, non-fatal MI/stroke, urgent revascularization).","Substantially lower Lp(a) levels achieved consistent with prior studies; acceptable safety profile; full data at upcoming medical congress.","Ionis discovered pelacarsen; Novartis licensed rights in Feb 2019; CEO Monia says results inform future cardiovascular care.","Ionis continues independent commercialization of TRYNGOLZA, DAWNZERA, ZANVASTRO; pipeline otherwise unaffected."],"urls":{"canonical":"https://secwatch.observer/filing/0001140361-26-035802","json":"https://secwatch.observer/filing/0001140361-26-035802.json","markdown":"https://secwatch.observer/filing/0001140361-26-035802.md","text":"https://secwatch.observer/filing/0001140361-26-035802.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/874015/000114036126035802/0001140361-26-035802-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/874015/000114036126035802/ef20081690_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-09-04T21:02:15.485953+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}