{"schema_version":"secwatch.filing_event.v1","accession":"0001157523-23-001060","form_type":"8-K","ticker":"SRRK","cik":"0001727196","company_name":"Scholar Rock Holding Corp","filed_at":"2023-06-30T23:59:59+00:00","discovered_at":"2026-05-14T18:03:40.263439+00:00","generated_at":"2026-06-13T14:11:36.460320+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Scholar Rock reports 36-month TOPAZ data: sustained motor function and safety; Phase 3 on track","bullets":["Mean HFMSE change from baseline at 36 months: +4.0 points (95% CI 1.0-6.9, N=28).","Mean RULM change from baseline at 36 months: +2.4 points (95% CI 1.1-3.7, N=27).","PEDI-CAT daily activity +2.2; PROMIS-Fatigue -4.6 at 36 months, consistent with motor gains.","Safety: 198 patient-years exposure; >90% remained on study; no new safety signals or ADA.","Phase 3 SAPPHIRE enrollment expected to complete Q3 2023."],"urls":{"canonical":"https://secwatch.observer/filing/0001157523-23-001060","json":"https://secwatch.observer/filing/0001157523-23-001060.json","markdown":"https://secwatch.observer/filing/0001157523-23-001060.md","text":"https://secwatch.observer/filing/0001157523-23-001060.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1727196/000115752323001060/0001157523-23-001060-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1727196/000115752323001060/a53438186.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-13T14:11:36.460320+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}