---
schema_version: "secwatch.filing_event.v1"
accession: "0001157523-23-001060"
form_type: "8-K"
ticker: "SRRK"
cik: "0001727196"
company_name: "Scholar Rock Holding Corp"
filed_at: "2023-06-30T23:59:59+00:00"
generated_at: "2026-06-13T14:11:36.460320+00:00"
event_type: "other_material"
sentiment: "positive"
materiality_score: 0.75
calibrated_materiality_score: 0.75
confidence: "high"
source: SEC EDGAR
---

# Scholar Rock reports 36-month TOPAZ data: sustained motor function and safety; Phase 3 on track

## Summary
- Mean HFMSE change from baseline at 36 months: +4.0 points (95% CI 1.0-6.9, N=28).
- Mean RULM change from baseline at 36 months: +2.4 points (95% CI 1.1-3.7, N=27).
- PEDI-CAT daily activity +2.2; PROMIS-Fatigue -4.6 at 36 months, consistent with motor gains.
- Safety: 198 patient-years exposure; >90% remained on study; no new safety signals or ADA.
- Phase 3 SAPPHIRE enrollment expected to complete Q3 2023.

## SEC filing metadata
- accession: 0001157523-23-001060
- form_type: 8-K
- ticker: SRRK
- cik: 0001727196
- company_name: Scholar Rock Holding Corp
- filed_at: 2023-06-30T23:59:59+00:00
- event_type: other_material
- sentiment: positive
- materiality_score: 0.75
- calibrated_materiality_score: 0.75
- confidence: high
- sec_items: 7.01, 8.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1727196/000115752323001060/0001157523-23-001060-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1727196/000115752323001060/a53438186.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001157523-23-001060
- JSON: https://secwatch.observer/filing/0001157523-23-001060.json
- Plain text: https://secwatch.observer/filing/0001157523-23-001060.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.