earnings
confidence high
sentiment neutral
materiality 0.75
Aptose reports Q3 net loss $9.8M; tuspetinib completes dose escalation with CRs in FLT3+ AML
Aptose Biosciences Inc.
2022-Q3 EPS reported
-$0.34
- Net loss $9.8M ($0.11/share) vs $11.3M ($0.13) in Q3 2021; cash $55.4M funds operations into Q1 2024.
- Tuspetinib (HM43239) completes Phase 1/2 dose escalation; 120mg selected for single-agent expansion, 80mg with venetoclax.
- FLT3-mutant patients with prior FLT3 inhibitor failure achieved complete remissions; responses also in FLT3 wildtype with TP53/NRAS.
- Luxeptinib G3 formulation shows ~18-fold bioavailability improvement; continuous dosing of 50mg Q12h to start shortly.
- USAN Council adopted generic name 'tuspetinib'; Aptose will use for all future references.