other material
confidence high
sentiment neutral
materiality 0.35
Arbutus doses first patient in Phase 2a triple combo arm adding nivolumab for chronic HBV
Arbutus Biopharma Corp
- First patient dosed in additional arm of AB-729 Phase 2a trial including nivolumab (Opdivo) with VTP-300.
- Arm evaluates low-dose nivolumab plus VTP-300 boosters after AB-729 and NA therapy to reduce HBsAg in chronic HBV.
- Preliminary data from this arm expected in 2024; original arm data expected H2 2023.
- Enrollment complete in original arm; approximately 20 patients to be enrolled in new open-label arm.