{"schema_version":"secwatch.filing_event.v1","accession":"0001171843-23-006716","form_type":"8-K","ticker":"BCRX","cik":"0000882796","company_name":"BIOCRYST PHARMACEUTICALS INC","filed_at":"2023-11-03T23:59:59+00:00","discovered_at":"2026-05-14T18:03:32.235845+00:00","generated_at":"2026-06-08T22:57:31.820671+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"BioCryst and Clearside partner to develop avoralstat for DME via SCS Microinjector; $5M upfront","bullets":["License agreement for avoralstat for diabetic macular edema using Clearside's SCS Microinjector.","BioCryst pays $5M upfront; Clearside eligible for up to $30M in clinical/regulatory milestones and up to $47.5M in sales milestones.","Avoralstat previously safe in Phase 3 HAE trial; high potency and low solubility suited for suprachoroidal delivery.","DME is common cause of vision loss; one-third of patients don't respond to anti-VEGF therapies.","BioCryst to host R&D Day today at 1:00 pm ET."],"urls":{"canonical":"https://secwatch.observer/filing/0001171843-23-006716","json":"https://secwatch.observer/filing/0001171843-23-006716.json","markdown":"https://secwatch.observer/filing/0001171843-23-006716.md","text":"https://secwatch.observer/filing/0001171843-23-006716.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/882796/000117184323006716/0001171843-23-006716-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/882796/000117184323006716/f8k_110323.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-08T22:57:31.820671+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}