BioCryst sells European ORLADEYO rights to Neopharmed Gentili for up to $264M

BIOCRYST PHARMACEUTICALS INC

Neopharmed Gentili pays $250M upfront, up to $14M milestones; closing expected by early October 2025.
Proceeds to retire all $249M remaining term debt, eliminating ~$70M future interest payments.
BioCryst now expects ~$700M cash and no term debt by end 2027, a $400M increase from prior guidance.
Sale includes European team; BioCryst saves at least $50M in annual operating expenses.
European ORLADEYO revenues still count toward global royalty tiers for OMERS and >$550M cap.

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