---
schema_version: "secwatch.filing_event.v1"
accession: "0001178913-25-000700"
form_type: "8-K"
ticker: "SLXN"
cik: "0002022416"
company_name: "Silexion Therapeutics Corp"
filed_at: "2025-03-05T23:59:59+00:00"
generated_at: "2026-05-25T11:45:53.834486+00:00"
event_type: "other_material"
sentiment: "positive"
materiality_score: 0.65
calibrated_materiality_score: 0.65
confidence: "high"
source: SEC EDGAR
---

# Silexion Therapeutics reports positive initial data from SIL204 in orthotopic pancreatic cancer models

## Summary
- SIL204 reduced primary tumor bioluminescence by ~70% in AsPC-1 (KRAS G12D) and ~80% in BxPC-3 (wild-type) models by day 28.
- In Panc-1 model, SIL204 decreased bioluminescence by 12% vs. baseline while control increased >100% (p<0.05) by day 14.
- Subcutaneous SIL204 significantly reduced metastatic spread to liver, intestine, spleen, and stomach in Panc-1 and BxPC-3 models.
- Data provide initial validation of systemic delivery efficacy for treating both primary tumors and metastases in orthotopic models.
- Company plans to provide updated development strategy leveraging systemic administration approach in coming weeks.

## SEC filing metadata
- accession: 0001178913-25-000700
- form_type: 8-K
- ticker: SLXN
- cik: 0002022416
- company_name: Silexion Therapeutics Corp
- filed_at: 2025-03-05T23:59:59+00:00
- event_type: other_material
- sentiment: positive
- materiality_score: 0.65
- calibrated_materiality_score: 0.65
- confidence: high
- sec_items: 7.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/2022416/000117891325000700/0001178913-25-000700-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/2022416/000117891325000700/zk2532812.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001178913-25-000700
- JSON: https://secwatch.observer/filing/0001178913-25-000700.json
- Plain text: https://secwatch.observer/filing/0001178913-25-000700.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.