other material
confidence high
sentiment positive
materiality 0.70
Silexion completes toxicology studies for SIL204; Phase 2/3 trial on track for Q2 2026
Silexion Therapeutics Corp
- Two-species toxicology studies for SIL204 confirm no systemic organ toxicity, clearing path to regulatory filings.
- Regulatory submissions planned to Israel Ministry of Health and Germany's BfArM ahead of Phase 2/3 trial.
- Phase 2/3 clinical trial in locally advanced pancreatic cancer (LAPC) expected to initiate in Q2 2026.
- CRO partner for the trial has been secured; SIL204 targets mutant KRAS oncogenes via siRNA.