{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-21-294159","form_type":"8-K","ticker":"ORIC","cik":"0001796280","company_name":"Oric Pharmaceuticals, Inc.","filed_at":"2021-10-07T23:59:59+00:00","discovered_at":"2026-05-14T18:04:14.176507+00:00","generated_at":"2026-06-28T22:20:54.181069+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"neutral","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"ORIC presents Phase 1b data on ORIC-101 in prostate cancer and preclinical data on ORIC-114","bullets":["ORIC-101 (240 mg) + enzalutamide well tolerated at RP2D; adverse events mostly Grade 1-2, consistent with enzalutamide alone.","No drug-drug interaction; plasma concentrations inhibited GR target; 76% of tumors had moderate-to-high GR expression.","In patients lacking AR resistance markers (n=8), those with moderate/high GR (n=6) had prolonged time on treatment vs low GR (n=2).","ORIC-114 showed superior brain penetration and tumor regressions in HER2+ breast cancer models; 90% CR in EGFR exon20 NSCLC xenograft."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-21-294159","json":"https://secwatch.observer/filing/0001193125-21-294159.json","markdown":"https://secwatch.observer/filing/0001193125-21-294159.md","text":"https://secwatch.observer/filing/0001193125-21-294159.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1796280/000119312521294159/0001193125-21-294159-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1796280/000119312521294159/d181647d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-28T22:20:54.181069+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}