{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-22-086854","form_type":"8-K","ticker":"KPTI","cik":"0001503802","company_name":"Karyopharm Therapeutics Inc.","filed_at":"2022-03-28T23:59:59+00:00","discovered_at":"2026-05-14T18:04:06.777600+00:00","generated_at":"2026-06-26T16:00:18.253539+00:00","sec_items":["5.02"],"event_type":"leadership","sentiment":"neutral","materiality_score":0.4,"calibrated_materiality_score":0.4,"confidence":"high","headline":"Karyopharm director Michael G. Kauffman resigns effective March 22, 2022","bullets":["Michael G. Kauffman, M.D., Ph.D. resigned from the Board of Directors effective immediately.","Resignation is not due to any disagreement with the Company's operations, policies or practices.","No replacement for the departing director has been announced."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-22-086854","json":"https://secwatch.observer/filing/0001193125-22-086854.json","markdown":"https://secwatch.observer/filing/0001193125-22-086854.md","text":"https://secwatch.observer/filing/0001193125-22-086854.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1503802/000119312522086854/0001193125-22-086854-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1503802/000119312522086854/d290356d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-26T16:00:18.253539+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[{"claim_id":"8f7e6c1952","claim":"Michael G. Kauffman resigned as Director at Karyopharm Therapeutics Inc..","evidence_excerpt":"On March 22, 2022, Michael G. Kauffman, M.D., Ph.D. notified Karyopharm Therapeutics Inc. (the “Company”) of his resignation from the Board of Directors, effective immediately.","evidence_source":"SEC 8-K Item 5.02","evidence_url":"https://www.sec.gov/Archives/edgar/data/1503802/000119312522086854/0001193125-22-086854-index.htm","confidence":0.95,"family_label":"Executive change","details":[{"label":"Action","value":"resigned"},{"label":"Role","value":"Director"}],"fact_type":"executive_change"}],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}