---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-22-137040"
form_type: "8-K"
ticker: "QNCX"
cik: "0001662774"
company_name: "Quince Therapeutics, Inc."
filed_at: "2022-05-02T23:59:59+00:00"
generated_at: "2026-06-26T02:07:02.424438+00:00"
event_type: "leadership"
sentiment: "negative"
materiality_score: 0.75
calibrated_materiality_score: 0.75
confidence: "high"
source: SEC EDGAR
---

# Cortexyme cuts 36% more staff (67% total); CMO Michael Detke departs May 2

## Summary
- Additional 36% headcount reduction, bringing total to 67% from January 2022 levels; majority by end of May 2022.
- Estimated $0.7M in cash expenses for severance and related costs.
- CMO Michael Detke to step down effective May 2, 2022; cash severance of $354,750 (9 months base salary).
- Additional cash severance and accelerated vesting if change in control within 3 months of departure.
- Cost reductions triggered by clinical hold on atuzaginstat (COR388) IND.

## SEC filing metadata
- accession: 0001193125-22-137040
- form_type: 8-K
- ticker: QNCX
- cik: 0001662774
- company_name: Quince Therapeutics, Inc.
- filed_at: 2022-05-02T23:59:59+00:00
- event_type: leadership
- sentiment: negative
- materiality_score: 0.75
- calibrated_materiality_score: 0.75
- confidence: high
- sec_items: 2.05, 5.02
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1662774/000119312522137040/0001193125-22-137040-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1662774/000119312522137040/d310630d8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-22-137040
- JSON: https://secwatch.observer/filing/0001193125-22-137040.json
- Plain text: https://secwatch.observer/filing/0001193125-22-137040.txt

## Key facts
- Executive change
  Michael Detke departed as Chief Medical Officer at Quince Therapeutics, Inc..
  - Action: stepped down
  - Role: Chief Medical Officer
  source text: Effective May 2, 2022 (the “Departure Date”), Michael Detke, M.D., Ph.D., the Company’s Chief Medical Officer, will step down from his position as the Chief Medical Officer.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1662774/000119312522137040/0001193125-22-137040-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.