---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-22-148082"
form_type: "8-K"
ticker: "SYBX"
cik: "0001527599"
company_name: "SYNLOGIC, INC."
filed_at: "2022-05-12T23:59:59+00:00"
generated_at: "2026-06-25T18:14:30.853376+00:00"
event_type: "earnings"
sentiment: "neutral"
materiality_score: 0.6
calibrated_materiality_score: 0.6
confidence: "high"
source: SEC EDGAR
---

# Synlogic reports Q1 net loss of $15.7M; cash $120.5M supports runway into 2024

## Summary
- Net loss of $15.7M ($0.22/share) vs $15.0M ($0.36/share) in Q1 2021.
- Revenue of $0.2M from Roche collaboration; no revenue in Q1 2021.
- Cash, cash equivalents and short-term investments $120.5M; expected funding into 2024.
- PKU program progressing to Phase 3 readiness; expects Phase 2 data and candidate selection in H2 2022.
- Michael Jensen appointed CFO in March 2022.

## SEC filing metadata
- accession: 0001193125-22-148082
- form_type: 8-K
- ticker: SYBX
- cik: 0001527599
- company_name: SYNLOGIC, INC.
- filed_at: 2022-05-12T23:59:59+00:00
- event_type: earnings
- sentiment: neutral
- materiality_score: 0.6
- calibrated_materiality_score: 0.6
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1527599/000119312522148082/0001193125-22-148082-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1527599/000119312522148082/d337665d8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-22-148082
- JSON: https://secwatch.observer/filing/0001193125-22-148082.json
- Plain text: https://secwatch.observer/filing/0001193125-22-148082.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.