{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-22-172488","form_type":"8-K","ticker":"QTTB","cik":"0001661998","company_name":"Q32 Bio Inc.","filed_at":"2022-06-13T23:59:59+00:00","discovered_at":"2026-05-14T18:04:01.694661+00:00","generated_at":"2026-06-25T02:23:27.725990+00:00","sec_items":["8.01"],"event_type":"regulatory","sentiment":"positive","materiality_score":0.8,"calibrated_materiality_score":0.8,"confidence":"high","headline":"FDA lifts clinical hold on Homology's pheNIX gene therapy trial for HMI-102 in PKU","bullets":["FDA lifted clinical hold on pheNIX trial (HMI-102) for phenylketonuria; company resolved all issues from March 17, 2022 hold.","Clinical hold related to elevated liver function tests, all resolved without hospitalizations.","Protocol changes include steroid-sparing immunosuppression with tacrolimus and shorter steroid course.","Company plans to provide program update in fall 2022."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-22-172488","json":"https://secwatch.observer/filing/0001193125-22-172488.json","markdown":"https://secwatch.observer/filing/0001193125-22-172488.md","text":"https://secwatch.observer/filing/0001193125-22-172488.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1661998/000119312522172488/0001193125-22-172488-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1661998/000119312522172488/d358045d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-25T02:23:27.725990+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}