{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-22-189446","form_type":"8-K","ticker":"SYRE","cik":"0001636282","company_name":"Spyre Therapeutics, Inc.","filed_at":"2022-07-07T23:59:59+00:00","discovered_at":"2026-05-14T18:03:56.480606+00:00","generated_at":"2026-06-24T19:40:17.408065+00:00","sec_items":["5.02"],"event_type":"leadership","sentiment":"neutral","materiality_score":0.25,"calibrated_materiality_score":0.25,"confidence":"high","headline":"Aeglea BioTherapeutics director Sandesh Mahatme resigns, effective July 8, 2022","bullets":["Sandesh Mahatme resigned as Class I director effective July 8, 2022.","Resignation not due to any disagreement with company operations, policies, or practices.","No replacement named at this time."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-22-189446","json":"https://secwatch.observer/filing/0001193125-22-189446.json","markdown":"https://secwatch.observer/filing/0001193125-22-189446.md","text":"https://secwatch.observer/filing/0001193125-22-189446.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1636282/000119312522189446/0001193125-22-189446-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1636282/000119312522189446/d274196d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-24T19:40:17.408065+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[{"claim_id":"3d113cab16","claim":"Sandesh Mahatme resigned as Class I Director at Spyre Therapeutics, Inc..","evidence_excerpt":"On July 6, 2022, Sandesh Mahatme advised the Board of Directors (the “Board”) of Aeglea BioTherapeutics, Inc. (the “Company”) that he would resign as a Class I director of the Board, effective on July 8, 2022.","evidence_source":"SEC 8-K Item 5.02","evidence_url":"https://www.sec.gov/Archives/edgar/data/1636282/000119312522189446/0001193125-22-189446-index.htm","confidence":0.95,"family_label":"Executive change","details":[{"label":"Action","value":"resigned"},{"label":"Role","value":"Class I Director"}],"fact_type":"executive_change"}],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}