---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-22-275812"
form_type: "8-K"
ticker: "AMLX"
cik: "0001658551"
company_name: "Amylyx Pharmaceuticals, Inc."
filed_at: "2022-11-02T23:59:59+00:00"
generated_at: "2026-06-22T14:23:28.952051+00:00"
event_type: "leadership"
sentiment: "neutral"
materiality_score: 0.25
calibrated_materiality_score: 0.25
confidence: "high"
source: SEC EDGAR
---

# Director Isaac Cheng resigns from Amylyx board effective Nov 1, 2022

## Summary
- Isaac Cheng, MD, resigned from the board of directors on November 1, 2022.
- Resignation is not due to any disagreement with the company on operations, policies, or accounting.
- Board size reduced by one; no replacement named in the filing.
- Company thanked Dr. Cheng for his service and contributions.

## SEC filing metadata
- accession: 0001193125-22-275812
- form_type: 8-K
- ticker: AMLX
- cik: 0001658551
- company_name: Amylyx Pharmaceuticals, Inc.
- filed_at: 2022-11-02T23:59:59+00:00
- event_type: leadership
- sentiment: neutral
- materiality_score: 0.25
- calibrated_materiality_score: 0.25
- confidence: high
- sec_items: 5.02
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1658551/000119312522275812/0001193125-22-275812-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1658551/000119312522275812/d374833d8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-22-275812
- JSON: https://secwatch.observer/filing/0001193125-22-275812.json
- Plain text: https://secwatch.observer/filing/0001193125-22-275812.txt

## Key facts
- Executive change
  Isaac Cheng resigned as Member of the Board of Directors at Amylyx Pharmaceuticals, Inc..
  - Action: resigned
  - Role: Member of the Board of Directors
  source text: On November 1, 2022, Isaac Cheng, MD, a member of the board of directors of Amylyx Pharmaceuticals, Inc. (the “Company”), submitted his resignation from the board of directors, effective as of close of business on November 1, 2022.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1658551/000119312522275812/0001193125-22-275812-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.