{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-23-145650","form_type":"8-K","ticker":"COYA","cik":"0001835022","company_name":"Coya Therapeutics, Inc.","filed_at":"2023-05-16T23:59:59+00:00","discovered_at":"2026-05-14T18:03:41.014885+00:00","generated_at":"2026-06-15T00:03:09.641873+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Coya Therapeutics' COYA 301 shows improved cognition and Treg expansion in Phase 1 AD study","bullets":["8 AD patients treated with monthly COYA 301 (low-dose IL-2) showed statistically significant improvement in MMSE scores (p=0.015) during treatment.","Treg percentage nearly doubled from 4.55% to 8.68% (p=0.0004); suppressive function increased from 46.6% to 79.5% (p=0.003).","Blood levels of pro-inflammatory cytokines IL-15, CCL2, and CCL11 were significantly lowered after each treatment cycle.","No serious adverse events; mild injection-site reactions and leukopenia; no patient discontinued the study."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-23-145650","json":"https://secwatch.observer/filing/0001193125-23-145650.json","markdown":"https://secwatch.observer/filing/0001193125-23-145650.md","text":"https://secwatch.observer/filing/0001193125-23-145650.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1835022/000119312523145650/0001193125-23-145650-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1835022/000119312523145650/d471671d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-15T00:03:09.641873+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}