other material
confidence high
sentiment positive
materiality 0.60
IN8bio preclinical data shows DeltEx gamma-delta T cells kill ovarian cancer cells, including resistant lines
IN8BIO, INC.
- Data presented at ASGCT 2023 demonstrate DeltEx T cells target and kill ovarian cancer cells even in platinum-resistant lines.
- Temozolomide (TMZ) combined with PARP inhibitors synergistically increased NKG2D-L expression, enhancing tumor cell visibility to gamma-delta T cells.
- CEO William Ho highlighted synergy of gamma-delta T cells with chemotherapy for solid tumors beyond the brain.
- CSO Lawrence Lamb noted potential for INB-400 in ovarian cancer and other solid tumors; further evaluation planned.
- Preclinical proof-of-concept supports DeltEx Drug Resistance Immunotherapy (DeltEx DRI) platform in challenging indications.