{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-23-148827","form_type":"8-K","ticker":"TSHA","cik":"0001806310","company_name":"Taysha Gene Therapies, Inc.","filed_at":"2023-05-19T23:59:59+00:00","discovered_at":"2026-05-14T18:03:40.692553+00:00","generated_at":"2026-06-14T19:59:53.302589+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"Taysha TSHA-102 data: safe in wild-type mice, extends survival >4x in Rett model","bullets":["New wild-type mouse data: TSHA-102 showed no toxicity or survival reduction over 36 weeks, no impact on neurobehavioral function.","In Mecp2–/Y knockout mice, TSHA-102 led to 47% survival at 36 weeks vs median 8.1 weeks in vehicle group (>4-fold extension, p<0.0001).","TSHA-102 significantly delayed onset of severe Rett phenotypes: severe clasping from ~7 to 21 weeks, abnormal gait from ~8 to 20 weeks.","Dosing of first adult patient in Phase 1/2 REVEAL trial expected Q2 2023; initial safety data anticipated Q2 2023.","TSHA-102 uses miRARE technology to regulate MeCP2 expression, addressing risks of both under- and overexpression in mosaic X-chromosome silencing."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-23-148827","json":"https://secwatch.observer/filing/0001193125-23-148827.json","markdown":"https://secwatch.observer/filing/0001193125-23-148827.md","text":"https://secwatch.observer/filing/0001193125-23-148827.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1806310/000119312523148827/0001193125-23-148827-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1806310/000119312523148827/d511724d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-14T19:59:53.302589+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}