{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-23-153420","form_type":"8-K","ticker":"ANNX","cik":"0001528115","company_name":"Annexon, Inc.","filed_at":"2023-05-25T23:59:59+00:00","discovered_at":"2026-05-14T18:03:39.261588+00:00","generated_at":"2026-06-14T14:28:42.352414+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"neutral","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Annexon ARCHER Ph2: ANX007 shows stat-sig vision loss protection, primary lesion growth endpoint missed","bullets":["ANX007 monthly reduced risk of ≥15-letter BCVA loss by 72% (p=0.006); pooled 59% (p=0.008).","Primary endpoint GA lesion growth rate reduction not met: monthly 6.2% (p=0.526), EOM 1.3% (p=0.896).","ANX007 well-tolerated; 3 SAEs endophthalmitis (injection-related), 3 SAEs intraocular inflammation suspected treatment-related.","First complement therapy to show preservation of visual function in a prospective 12-month GA trial.","Company plans regulatory engagement for optimal path forward; webcast today 1:30pm PT."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-23-153420","json":"https://secwatch.observer/filing/0001193125-23-153420.json","markdown":"https://secwatch.observer/filing/0001193125-23-153420.md","text":"https://secwatch.observer/filing/0001193125-23-153420.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1528115/000119312523153420/0001193125-23-153420-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1528115/000119312523153420/d468662d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-14T14:28:42.352414+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}