{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-23-176864","form_type":"8-K","ticker":"TSHA","cik":"0001806310","company_name":"Taysha Gene Therapies, Inc.","filed_at":"2023-06-28T23:59:59+00:00","discovered_at":"2026-05-14T18:03:40.693657+00:00","generated_at":"2026-06-13T15:39:37.082739+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Taysha reports new TSHA-120 data analysis supports FDA path; TSHA-102 first patient dosed","bullets":["New TSHA-120 analysis shows 99% probability of slowing disease progression on mFARS and MFM32 Domain 3; FDA meeting expected Q3 2023.","First adult patient with Rett syndrome dosed with TSHA-102 in REVEAL Phase 1/2 trial; safety/efficacy update expected early Q3 2023.","CTA submission for TSHA-102 in pediatric Rett patients in UK mid-2023; IND submission to FDA H2 2023.","Over seven years of safety data support TSHA-120; DPM using natural history data supports external control for regulatory path."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-23-176864","json":"https://secwatch.observer/filing/0001193125-23-176864.json","markdown":"https://secwatch.observer/filing/0001193125-23-176864.md","text":"https://secwatch.observer/filing/0001193125-23-176864.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1806310/000119312523176864/0001193125-23-176864-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1806310/000119312523176864/d506285d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-13T15:39:37.082739+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}