other material
confidence high
sentiment negative
materiality 0.85
Vir Bio Phase 2 flu prevention trial misses endpoints; cash ~$1.9B
Vir Biotechnology, Inc.
- Phase 2 PENINSULA trial of VIR-2482 did not meet primary or secondary efficacy endpoints for preventing symptomatic influenza A.
- Highest dose (1,200 mg) showed non-statistically significant 16% reduction in protocol-defined influenza A illness vs placebo.
- Secondary endpoint (CDC-defined ILI) showed 57% reduction, but not statistically significant (95% CI -2.51 to 82.15).
- VIR-2482 was generally well tolerated; no safety signals identified; ~3,000 participants enrolled.
- Cash, cash equivalents and investments were approximately $1.9 billion as of June 30, 2023.