---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-23-231646"
form_type: "8-K"
ticker: "SYRE"
cik: "0001636282"
company_name: "Spyre Therapeutics, Inc."
filed_at: "2023-09-08T23:59:59+00:00"
generated_at: "2026-06-10T22:12:47.593877+00:00"
event_type: "other_material"
sentiment: "neutral"
materiality_score: 0.5
calibrated_materiality_score: 0.5
confidence: "high"
source: SEC EDGAR
---

# Aeglea Biotherapeutics effects 1-for-25 reverse stock split and reduces authorized shares to 20M

## Summary
- Reverse stock split at 1-for-25 ratio effective Sept 8, 2023; no fractional shares issued; cash in lieu.
- Authorized common shares reduced from 500M to 20M.
- Proportional adjustments to Series A preferred conversion, outstanding warrants, and equity awards.
- Corporate presentation: adjusted total capitalization ~47.7M shares as-converted as of June 22, 2023.
- 2022 net loss per share restated to $(24.86) on weighted-average shares of 3.37M post-split.

## SEC filing metadata
- accession: 0001193125-23-231646
- form_type: 8-K
- ticker: SYRE
- cik: 0001636282
- company_name: Spyre Therapeutics, Inc.
- filed_at: 2023-09-08T23:59:59+00:00
- event_type: other_material
- sentiment: neutral
- materiality_score: 0.5
- calibrated_materiality_score: 0.5
- confidence: high
- sec_items: 3.03, 5.03, 7.01, 8.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1636282/000119312523231646/0001193125-23-231646-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1636282/000119312523231646/d548916d8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-23-231646
- JSON: https://secwatch.observer/filing/0001193125-23-231646.json
- Plain text: https://secwatch.observer/filing/0001193125-23-231646.txt

## Key facts
- Governance Changes
  Spyre Therapeutics, Inc.: Filed Certificate of Amendment to Restated Certificate of Incorporation to effect a 1-for-25 reverse stock split and reduction of authorized shares from 500,000,000 to 20,000,000 (effective 2023-09-08).
  - Change: charter amendment
  - Effective: 2023-09-08
  source text: To effect the Reverse Stock Split and the Authorized Shares Reduction, on September 7, 2023, the Company filed a Certificate of Amendment to its Restated Certificate of Incorporation with the Secretary of State of the State of Delaware (the “Amendment”).
  evidence_url: https://www.sec.gov/Archives/edgar/data/1636282/000119312523231646/0001193125-23-231646-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.