{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-23-245724","form_type":"8-K","ticker":"WVE","cik":"0001631574","company_name":"Wave Life Sciences Ltd.","filed_at":"2023-09-28T23:59:59+00:00","discovered_at":"2026-05-14T18:03:34.622601+00:00","generated_at":"2026-06-10T07:38:54.493562+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"Wave Life Sciences unveils INHBE siRNA for obesity, targets 5 new clinical candidates by 2025","bullets":["New GalNAc-siRNA program targeting INHBE for metabolic disorders including obesity; expects clinical candidate in 4Q 2024.","INHBE knockdown of 62% in DIO mice led to 16% lower body weight vs control at 5 weeks; visceral fat reduction in 8-week study.","WVE-006 for AATD: dosing in healthy volunteers expected 4Q 2023; proof-of-mechanism data in AATD patients in 2024.","Plans to select five new clinical candidates by year-end 2025, spanning RNA editing (correction and upregulation) and siRNA.","WVE-N531 in DMD: muscle biopsy data show uptake in satellite cells after 3 doses; data from registrational Phase 2 (FORWARD-53) expected 2024."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-23-245724","json":"https://secwatch.observer/filing/0001193125-23-245724.json","markdown":"https://secwatch.observer/filing/0001193125-23-245724.md","text":"https://secwatch.observer/filing/0001193125-23-245724.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1631574/000119312523245724/0001193125-23-245724-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1631574/000119312523245724/d537767d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-10T07:38:54.493562+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}