other material
confidence high
sentiment positive
materiality 0.75
ALX Oncology reports positive interim Phase 2 ASPEN-06 data for evorpacept in HER2+ gastric cancer
ALX ONCOLOGY HOLDINGS INC
- Confirmed ORR 52% for evorpacept combo vs 22% control; median DOR not reached vs 7.4 months.
- First positive randomized data for any CD47 blocker in solid tumors; safety consistent with prior trials.
- Phase 3 ASPEN-06 initiation planned late 2024; final Phase 2 results expected Q2 2024.
- Stratification factors (2nd/3rd line, prior ENHERTU) prespecified and balanced per protocol.