---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-23-253882"
form_type: "8-K"
ticker: "TPST"
cik: "0001544227"
company_name: "Tempest Therapeutics, Inc."
filed_at: "2023-10-11T23:59:59+00:00"
generated_at: "2026-06-10T01:39:16.610413+00:00"
event_type: "other_material"
sentiment: "positive"
materiality_score: 0.8
calibrated_materiality_score: 0.8
confidence: "high"
source: SEC EDGAR
---

# Tempest TPST-1120 achieves 30% ORR vs 13.3% control in randomized HCC study; adopts poison pill

## Summary
- Confirmed ORR 30% for TPST-1120 arm vs 13.3% control; duration of response not reached.
- PFS HR 0.7 (median 7 mo vs 4.27 mo); OS HR 0.59 (median not reached vs 15.1 mo).
- In beta-catenin mutation patients, cORR 43% and DCR 100%; in PD-L1 negative, cORR 27% vs 7% control.
- Adopted limited duration rights plan; triggers at 10% (15% passive); expires Oct 2024 or 2026 if approved.
- 40% of TPST-1120 arm patients remain on treatment vs 16.7% control; safety comparable between arms.

## SEC filing metadata
- accession: 0001193125-23-253882
- form_type: 8-K
- ticker: TPST
- cik: 0001544227
- company_name: Tempest Therapeutics, Inc.
- filed_at: 2023-10-11T23:59:59+00:00
- event_type: other_material
- sentiment: positive
- materiality_score: 0.8
- calibrated_materiality_score: 0.8
- confidence: high
- sec_items: 1.01, 3.03, 5.03, 8.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1544227/000119312523253882/0001193125-23-253882-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1544227/000119312523253882/d547808d8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-23-253882
- JSON: https://secwatch.observer/filing/0001193125-23-253882.json
- Plain text: https://secwatch.observer/filing/0001193125-23-253882.txt

## Key facts
- Material Agreements
  Tempest Therapeutics, Inc. entered into Rights Agreement with Computershare Trust Company, N.A. (effective 2023-10-10).
  - Action: entry
  - Counterparty: Computershare Trust Company, N.A.
  - Effective: 2023-10-10
  source text: the Rights Agreement, dated as of October 10, 2023 (the “Rights Agreement”), by and between the Company and Computershare Trust Company, N.A., as Rights Agent
  evidence_url: https://www.sec.gov/Archives/edgar/data/1544227/000119312523253882/0001193125-23-253882-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.