{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-23-256537","form_type":"8-K","ticker":"RARE","cik":"0001515673","company_name":"Ultragenyx Pharmaceutical Inc.","filed_at":"2023-10-16T23:59:59+00:00","discovered_at":"2026-05-14T18:03:29.332081+00:00","generated_at":"2026-06-09T23:16:47.979649+00:00","sec_items":["2.02","7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"Ultragenyx reports prelim Q3 rev $96-100M; UX143 cuts fractures 67% in Phase 2","bullets":["Prelim Q3 total rev $96-100M; Crysvita $74-76M (impacted by inventory shift to KKC); cash $525M.","Setrusumab (UX143) cut annualized fracture rate 67% (p=0.042) in Phase 2; BMD +13-16% at 6 months.","GTX-102 for Angelman: clinically meaningful improvements vs natural history; no new SAEs since Nov 2022.","UX701 for Wilson: 4/5 low-dose patients tapering off chelators; 2 completely off standard therapy.","Gene therapy: DTX401 Phase 3 fully enrolled; UX111 fully enrolled; DTX301 enrollment expected H1 2024."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-23-256537","json":"https://secwatch.observer/filing/0001193125-23-256537.json","markdown":"https://secwatch.observer/filing/0001193125-23-256537.md","text":"https://secwatch.observer/filing/0001193125-23-256537.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1515673/000119312523256537/0001193125-23-256537-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1515673/000119312523256537/d548890d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-09T23:16:47.979649+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}