{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-23-260795","form_type":"8-K","ticker":"ORIC","cik":"0001796280","company_name":"Oric Pharmaceuticals, Inc.","filed_at":"2023-10-23T23:59:59+00:00","discovered_at":"2026-05-14T18:03:30.495036+00:00","generated_at":"2026-06-09T17:04:34.519973+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"ORIC-114 Phase 1 data shows first confirmed CNS complete response in EGFR exon 20 NSCLC","bullets":["81% of EGFR exon 20 NSCLC patients had prior exon 20 targeted agents; 86% had CNS metastases at baseline.","At 75 mg QD (potential RP2D): 67% unconfirmed ORR and 33% confirmed ORR in post-amivantamab patients (n=3).","First confirmed CNS complete response reported by an EGFR exon 20 inhibitor in untreated brain metastases.","HER2 exon 20 patients: partial responses observed, including 100% target lesion regression.","Favorable safety: mostly Grade 1-2 TRAEs; no Grade 3+ rash; 4% discontinuations; MTD not reached."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-23-260795","json":"https://secwatch.observer/filing/0001193125-23-260795.json","markdown":"https://secwatch.observer/filing/0001193125-23-260795.md","text":"https://secwatch.observer/filing/0001193125-23-260795.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1796280/000119312523260795/0001193125-23-260795-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1796280/000119312523260795/d561418d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-09T17:04:34.519973+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}