{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-23-268935","form_type":"8-K","ticker":"IRON","cik":"0001816736","company_name":"Disc Medicine, Inc.","filed_at":"2023-11-02T23:59:59+00:00","discovered_at":"2026-05-14T18:03:30.629630+00:00","generated_at":"2026-06-09T00:51:36.921926+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Disc Medicine completes EPP trial enrollment; bitopertin shows PPIX reduction and light tolerance gains","bullets":["Enrollment complete for Phase 2 BEACON (n=22 adults) and AURORA (n=75 adults) bitopertin trials in EPP; BEACON expanded to adolescents.","Interim BEACON data: mean PPIX reduction of 39% by Day 43; patients with >30% PPIX reduction averaged >10 hours weekly sunlight tolerance improvement.","Proportion of prodrome-free sunlight challenges rose from 2% to 49%; phototoxic reactions decreased 93% on bitopertin.","Initial DISC-0974 data in MF with anemia shows dose-dependent hepcidin reductions and serum iron increases; no serious AEs reported.","Updated BEACON data and preliminary DISC-0974 results to be presented at ASH Dec 11; conference call same day at 9:30 PM ET."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-23-268935","json":"https://secwatch.observer/filing/0001193125-23-268935.json","markdown":"https://secwatch.observer/filing/0001193125-23-268935.md","text":"https://secwatch.observer/filing/0001193125-23-268935.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1816736/000119312523268935/0001193125-23-268935-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1816736/000119312523268935/d569217d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-09T00:51:36.921926+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}