{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-23-286862","form_type":"8-K","ticker":"STOK","cik":"0001623526","company_name":"Stoke Therapeutics, Inc.","filed_at":"2023-12-01T23:59:59+00:00","discovered_at":"2026-05-14T18:03:29.822678+00:00","generated_at":"2026-06-07T19:23:33.190910+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Stoke presents STK-001 data at AES 2023: seizure reductions and cognition gains in Dravet syndrome","bullets":["Higher STK-001 brain exposure linked to greater seizure reductions in 72 patients (R=-0.23, P<0.001).","Multiple 70mg doses of STK-001 showed the largest reductions in convulsive seizure frequency.","90% of Phase 1/2a completers enrolled in open-label extension studies (SWALLOWTAIL & LONGWING).","BUTTERFLY natural history study: patients on ~3.5 anti-seizure drugs saw no meaningful seizure improvement over 2 years.","OLE data showed substantial improvements in cognition and behavior over 12 months, supporting disease modification."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-23-286862","json":"https://secwatch.observer/filing/0001193125-23-286862.json","markdown":"https://secwatch.observer/filing/0001193125-23-286862.md","text":"https://secwatch.observer/filing/0001193125-23-286862.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1623526/000119312523286862/0001193125-23-286862-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1623526/000119312523286862/d619524d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-07T19:23:33.190910+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}