{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-23-291208","form_type":"8-K","ticker":"KPTI","cik":"0001503802","company_name":"Karyopharm Therapeutics Inc.","filed_at":"2023-12-08T23:59:59+00:00","discovered_at":"2026-05-14T18:03:29.290272+00:00","generated_at":"2026-06-07T15:32:50.252875+00:00","sec_items":["5.02"],"event_type":"leadership","sentiment":"neutral","materiality_score":0.3,"calibrated_materiality_score":0.3,"confidence":"high","headline":"Director Peter K. Honig resigns from Karyopharm board, effective Dec 31, 2023","bullets":["Peter K. Honig, M.D., MPH, resigns from Board of Directors effective Dec 31, 2023.","Departure due to competing professional demands; no disagreement with the Company.","No replacement announced; resignation reduces board size."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-23-291208","json":"https://secwatch.observer/filing/0001193125-23-291208.json","markdown":"https://secwatch.observer/filing/0001193125-23-291208.md","text":"https://secwatch.observer/filing/0001193125-23-291208.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1503802/000119312523291208/0001193125-23-291208-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1503802/000119312523291208/d614002d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-07T15:32:50.252875+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[{"claim_id":"9fac521cde","claim":"Peter K Honig resigned as member of the Board of Directors at Karyopharm Therapeutics Inc..","evidence_excerpt":"On December 5, 2023, Peter K Honig, M.D., MPH, a member of the Board of Directors (the “Board”) of Karyopharm Therapeutics Inc. (the “Company”), notified the Company of his resignation from the Board, effective as of December 31, 2023.","evidence_source":"SEC 8-K Item 5.02","evidence_url":"https://www.sec.gov/Archives/edgar/data/1503802/000119312523291208/0001193125-23-291208-index.htm","confidence":0.95,"family_label":"Executive change","details":[{"label":"Action","value":"resigned"},{"label":"Role","value":"member of the Board of Directors"}],"fact_type":"executive_change"}],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}