---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-23-291208"
form_type: "8-K"
ticker: "KPTI"
cik: "0001503802"
company_name: "Karyopharm Therapeutics Inc."
filed_at: "2023-12-08T23:59:59+00:00"
generated_at: "2026-06-07T15:32:50.252875+00:00"
event_type: "leadership"
sentiment: "neutral"
materiality_score: 0.3
calibrated_materiality_score: 0.3
confidence: "high"
source: SEC EDGAR
---

# Director Peter K. Honig resigns from Karyopharm board, effective Dec 31, 2023

## Summary
- Peter K. Honig, M.D., MPH, resigns from Board of Directors effective Dec 31, 2023.
- Departure due to competing professional demands; no disagreement with the Company.
- No replacement announced; resignation reduces board size.

## SEC filing metadata
- accession: 0001193125-23-291208
- form_type: 8-K
- ticker: KPTI
- cik: 0001503802
- company_name: Karyopharm Therapeutics Inc.
- filed_at: 2023-12-08T23:59:59+00:00
- event_type: leadership
- sentiment: neutral
- materiality_score: 0.3
- calibrated_materiality_score: 0.3
- confidence: high
- sec_items: 5.02
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1503802/000119312523291208/0001193125-23-291208-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1503802/000119312523291208/d614002d8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-23-291208
- JSON: https://secwatch.observer/filing/0001193125-23-291208.json
- Plain text: https://secwatch.observer/filing/0001193125-23-291208.txt

## Key facts
- Executive change
  Peter K Honig resigned as member of the Board of Directors at Karyopharm Therapeutics Inc..
  - Action: resigned
  - Role: member of the Board of Directors
  source text: On December 5, 2023, Peter K Honig, M.D., MPH, a member of the Board of Directors (the “Board”) of Karyopharm Therapeutics Inc. (the “Company”), notified the Company of his resignation from the Board, effective as of December 31, 2023.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1503802/000119312523291208/0001193125-23-291208-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.