{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-23-292306","form_type":"8-K","ticker":"IRON","cik":"0001816736","company_name":"Disc Medicine, Inc.","filed_at":"2023-12-11T23:59:59+00:00","discovered_at":"2026-05-14T18:03:30.630442+00:00","generated_at":"2026-06-07T15:01:47.543233+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Disc Medicine initial Phase 1b/2 data: DISC-0974 shows dose-dependent hepcidin reduction and Hb improvement in MF anemia","bullets":["DISC-0974 reduced serum hepcidin >75% and increased serum iron >75% at 28 mg dose.","57% (4/7) of evaluable non-transfusion-dependent patients achieved ≥1.5 g/dL hemoglobin increase.","One of two transfusion-dependent patients achieved transfusion independence per Gale Criteria.","Hematologic activity observed regardless of concomitant JAK inhibitor use; drug generally well-tolerated.","Data presented at ASH 2023; dose escalation ongoing with 11 evaluable subjects from three dose levels."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-23-292306","json":"https://secwatch.observer/filing/0001193125-23-292306.json","markdown":"https://secwatch.observer/filing/0001193125-23-292306.md","text":"https://secwatch.observer/filing/0001193125-23-292306.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1816736/000119312523292306/0001193125-23-292306-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1816736/000119312523292306/d644657d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-07T15:01:47.543233+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}