{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-23-292799","form_type":"8-K","ticker":"IRON","cik":"0001816736","company_name":"Disc Medicine, Inc.","filed_at":"2023-12-12T23:59:59+00:00","discovered_at":"2026-05-14T18:03:30.630710+00:00","generated_at":"2026-06-07T14:20:13.850115+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"Disc Medicine reports positive updated Phase 2 BEACON data for bitopertin; PPIX drops >40%, sunlight tolerance improves","bullets":["PPIX levels reduced >40% (p<0.001) from baseline; sustained and dose-dependent in 22 EPP patients.","Time to prodrome improved >3x; proportion of days without symptoms rose to 78% vs 33% baseline.","Mean cumulative time in light over 6 months: 222.6 hours (>3x historical control) on precedented pivotal endpoint.","Bitopertin well-tolerated with no serious AEs; stable mean hemoglobin, no anemia events reported.","Initial positive Phase 1b data for DISC-0974 in myelofibrosis showed hemoglobin improvements and reduced transfusions."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-23-292799","json":"https://secwatch.observer/filing/0001193125-23-292799.json","markdown":"https://secwatch.observer/filing/0001193125-23-292799.md","text":"https://secwatch.observer/filing/0001193125-23-292799.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1816736/000119312523292799/0001193125-23-292799-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1816736/000119312523292799/d638553d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-07T14:20:13.850115+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}