{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-24-000991","form_type":"8-K","ticker":"DYN","cik":"0001818794","company_name":"Dyne Therapeutics, Inc.","filed_at":"2024-01-03T23:59:59+00:00","discovered_at":"2026-05-14T18:03:25.669053+00:00","generated_at":"2026-06-07T04:47:10.196549+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.9,"calibrated_materiality_score":0.9,"confidence":"high","headline":"Dyne Therapeutics announces positive initial clinical data from ACHIEVE and DELIVER trials","bullets":["DYNE-101 in ACHIEVE trial: 19% mean splicing correction at 3.4 mg/kg at 3 months; 3.8 sec myotonia benefit at 1.8 mg/kg at 6 months.","DYNE-251 in DELIVER trial: 0.88% mean dystrophin expression at 5 mg/kg at 6 months, exceeding eteplirsen with 24-fold lower dose.","Favorable safety profiles: no related serious adverse events; dose escalation to 6.8 mg/kg (ACHIEVE) and 40 mg/kg (DELIVER) supported.","Company plans to initiate registrational cohorts for both programs by end of 2024, with next data updates in second half of 2024."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-24-000991","json":"https://secwatch.observer/filing/0001193125-24-000991.json","markdown":"https://secwatch.observer/filing/0001193125-24-000991.md","text":"https://secwatch.observer/filing/0001193125-24-000991.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1818794/000119312524000991/0001193125-24-000991-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1818794/000119312524000991/d586587d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-07T04:47:10.196549+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}