other material
confidence high
sentiment negative
materiality 0.85
AN2 Therapeutics pauses Phase 3 enrollment in epetraborole trial after efficacy concern
AN2 Therapeutics, Inc.
- Voluntary pause of Phase 3 enrollment in EBO-301 trial for treatment-refractory MAC lung disease.
- Blinded aggregate analysis showed potentially lower than expected efficacy; no safety concerns cited.
- Phase 2 part completed enrollment with 80 patients; Phase 3 had enrolled nearly 100 patients to date.
- Enrolled patients allowed to continue; topline Phase 2 data expected summer 2024.