{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-24-065913","form_type":"8-K","ticker":"CRNX","cik":"0001658247","company_name":"Crinetics Pharmaceuticals, Inc.","filed_at":"2024-03-12T23:59:59+00:00","discovered_at":"2026-05-14T18:03:25.004300+00:00","generated_at":"2026-06-04T23:04:01.669572+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Crinetics reports positive Phase 2 results for paltusotine in carcinoid syndrome","bullets":["Phase 2 trial: 63% reduction in mean flushing frequency (p<0.0001) for patients with >1/day at baseline.","60% reduction in mean excess bowel movements (p=0.02) for patients with >3/day at baseline; 61% reduction in flushing severity (p<0.0001).","Paltusotine generally well-tolerated; no treatment-related severe or serious AEs; common AEs included diarrhea, abdominal pain, nausea, headache.","Company plans to engage FDA to align on Phase 3 design; expects to initiate Phase 3 program by end of 2024."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-24-065913","json":"https://secwatch.observer/filing/0001193125-24-065913.json","markdown":"https://secwatch.observer/filing/0001193125-24-065913.md","text":"https://secwatch.observer/filing/0001193125-24-065913.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1658247/000119312524065913/0001193125-24-065913-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1658247/000119312524065913/d759755d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-04T23:04:01.669572+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}