earnings
confidence high
sentiment positive
materiality 0.85
Taysha reports 2023 net loss of $111.6M; TSHA-102 shows sustained improvements in Rett patients
Taysha Gene Therapies, Inc.
- Revenue of $15.5M for full-year 2023 (up from $2.5M in 2022) from Astellas option agreement.
- Net loss of $111.6M ($0.96 loss per basic share) vs. $166.0M ($3.78/share) in 2022; includes $34.5M non-cash warrant expense.
- Cash and equivalents of $143.9M as of Dec 31, 2023; cash runway expected into 2026.
- TSHA-102 low dose (5.7x10^14 vg) in REVEAL adult trial: well-tolerated, no SAEs; patient 1 shows improved sitting, sleep, social interaction at week 35; patient 2 shows reduced seizures at week 19.
- IDMC approved early dose escalation to high dose (1x10^15 vg) in adult/pediatric trials; initial pediatric low-dose data due mid-2024.