{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-24-083352","form_type":"8-K","ticker":"BMEA","cik":"0001840439","company_name":"Biomea Fusion, Inc.","filed_at":"2024-04-01T23:59:59+00:00","discovered_at":"2026-05-14T18:03:20.659076+00:00","generated_at":"2026-06-04T04:55:07.100532+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.7,"calibrated_materiality_score":0.7,"confidence":"medium","headline":"Biomea Fusion reports initial data from first two T1D patients dosed with BMF-219; C-peptide increased","bullets":["Patient 1 (200 mg): fasting C-peptide +57% at week 4, +80% at week 8; MMTT C-peptide index AUC +12% and +40%.","Patient 2 (100 mg): fasting C-peptide +16% at week 4; MMTT C-peptide index AUC +30%; reduced daily insulin usage.","BMF-219 well tolerated in both patients; no safety signals reported.","Open-label portion of COVALENT-112 (n=40) with 12-week dosing data expected in 2024.","First type 2 diabetes patient in COVALENT-111 discontinued metformin after week 40 with improved glycemic control."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-24-083352","json":"https://secwatch.observer/filing/0001193125-24-083352.json","markdown":"https://secwatch.observer/filing/0001193125-24-083352.md","text":"https://secwatch.observer/filing/0001193125-24-083352.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1840439/000119312524083352/0001193125-24-083352-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1840439/000119312524083352/d765540d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-04T04:55:07.100532+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}