{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-24-084937","form_type":"8-K","ticker":"IRON","cik":"0001816736","company_name":"Disc Medicine, Inc.","filed_at":"2024-04-02T23:59:59+00:00","discovered_at":"2026-05-14T18:03:20.313058+00:00","generated_at":"2026-06-04T03:46:29.217116+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"neutral","materiality_score":0.7,"calibrated_materiality_score":0.7,"confidence":"high","headline":"Disc Medicine bitopertin Phase 2 in EPP meets primary endpoint; key secondary misses significance","bullets":["Primary endpoint met: PPIX reduced 21.6% (20mg, p=0.003) and 40.7% (60mg, p<0.001) vs placebo +8.0%.","Key secondary (cumulative sunlight time) not significant: 175.1h (20mg), 153.1h (60mg) vs 133.9h placebo due to strong placebo response.","Phototoxic reactions with pain reduced 75% for 60mg (p=0.011) and 60% for 20mg (p=0.109).","Patient Global Impression of Change: 86% of 60mg completers rated 'much better' vs 50% placebo (p=0.022).","Bitopertin well tolerated, no SAEs; dizziness most common AE; two discontinuations at 60mg."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-24-084937","json":"https://secwatch.observer/filing/0001193125-24-084937.json","markdown":"https://secwatch.observer/filing/0001193125-24-084937.md","text":"https://secwatch.observer/filing/0001193125-24-084937.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1816736/000119312524084937/0001193125-24-084937-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1816736/000119312524084937/d815786d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-04T03:46:29.217116+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}