Codexis achieves enzymatic synthesis of full-length siRNA oligonucleotide; launches RNA ligase services

CODEXIS, INC.

Successfully synthesized a full-length siRNA oligonucleotide using ECO Synthesis enzymatic platform, including a conjugation moiety.
Coupling efficiency exceeded 98%; no notable impurities typical of phosphoramidite chemical synthesis were observed.
Launched RNA Ligase Screening and Optimization Services for custom evolution of dsRNA ligase enzymes and protocol optimization.
CEO Stephen Dilly highlighted rapid progress since ECO Synthesis platform unveiling at TIDES USA 2023; multiple customer meetings scheduled.

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