{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-24-161089","form_type":"8-K","ticker":"CABA","cik":"0001759138","company_name":"Cabaletta Bio, Inc.","filed_at":"2024-06-14T23:59:59+00:00","discovered_at":"2026-05-14T18:03:19.927045+00:00","generated_at":"2026-06-01T04:22:38.583885+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.78,"calibrated_materiality_score":0.78,"confidence":"high","headline":"CABA-201 shows no CRS/ICANS/SAEs in first two patients; B cell depletion and disease score improvements observed","bullets":["First patient in IMNM cohort had creatinine kinase drop from 617 to 308 and TIS of 30 at week 12.","First SLE patient had SLEDAI-2K score drop from 26 to 10 at week 4.","Complete B cell depletion by day 15 post-infusion; immature naïve B cell repopulation seen at week 8 in IMNM patient.","All chronic maintenance therapies discontinued for both patients except planned prednisone taper for SLE patient.","18 sites open, 5 patients enrolled as of June 12, 2024; initial data support current dose of 1e6 cells/kg."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-24-161089","json":"https://secwatch.observer/filing/0001193125-24-161089.json","markdown":"https://secwatch.observer/filing/0001193125-24-161089.md","text":"https://secwatch.observer/filing/0001193125-24-161089.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1759138/000119312524161089/0001193125-24-161089-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1759138/000119312524161089/d851455d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-01T04:22:38.583885+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}